Author Johnsen, Steven A.

• 2024 | Journal Article | 
  ​ ​USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration​
  Prokakis, E.; Bamahmoud, H.; Jansari, S.; Fritsche, L.; Dietz, A.; Boshnakovska, A. & Rehling, P. et al.​ (2024) 
  Cell Communication and Signaling, 22(1) art. 120​.​ DOI: https://doi.org/10.1186/s12964-023-01441-5 
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• 2021 | Journal Article | 
  ​ ​Store-Operated Calcium Entry: Shaping the Transcriptional and Epigenetic Landscape in Pancreatic Cancer​
  Kutschat, A. P.; Johnsen, S. A. & Hamdan, F. H.​ (2021) 
  Cells, 10(5).​ DOI: https://doi.org/10.3390/cells10050966 
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• 2021 | Journal Article | Research Paper
  ​ ​STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer​
  Kutschat, A. P.; Hamdan, F. H.; Wang, X.; Wixom, A. Q.; Najafova, Z.; Gibhardt, C. S. & Kopp, W. et al.​ (2021) 
  Cancer Research, art. canres.2874.2020​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-20-2874 
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• 2021 | Journal Article | 
  ​ ​USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response​
  Prokakis, E.; Dyas, A.; Grün, R.; Fritzsche, S.; Bedi, U.; Kazerouni, Z. B. & Kosinsky, R. L. et al.​ (2021) 
  Oncogene,.​ DOI: https://doi.org/10.1038/s41388-021-01814-5 
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• 2021 | Journal Article | 
  ​ ​RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease​
  Kosinsky, R. L.; Zerche, M.; Kutschat, A. P.; Nair, A.; Ye, Z.; Saul, D. & von Heesen, M. et al.​ (2021) 
  Cell Death and Differentiation,.​ DOI: https://doi.org/10.1038/s41418-021-00808-w 
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• 2021 | Journal Article | 
  ​ ​USP22 Suppresses SPARC Expression in Acute Colitis and Inflammation-Associated Colorectal Cancer​
  Kosinsky, R. L.; Saul, D.; Ammer-Herrmenau, C.; Faubion, W. A.; Neesse, A. & Johnsen, S. A.​ (2021) 
  Cancers, 13(8) pp. 1817​.​ DOI: https://doi.org/10.3390/cancers13081817 
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• 2021 | Journal Article | 
  ​ ​Telomerase and Pluripotency Factors Jointly Regulate Stemness in Pancreatic Cancer Stem Cells​
  Walter, K.; Rodriguez-Aznar, E.; Ferreira, M. S. V.; Frappart, P.-O.; Dittrich, T.; Tiwary, K. & Meessen, S. et al.​ (2021) 
  Cancers, 13(13) pp. 3145​.​ DOI: https://doi.org/10.3390/cancers13133145 
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• 2021 | Journal Article
  ​ ​Bromodomain protein BRDT directs ΔNp63 function and super-enhancer activity in a subset of esophageal squamous cell carcinomas​
  Wang, X.; Kutschat, A. P.; Yamada, M.; Prokakis, E.; Böttcher, P.; Tanaka, K. & Doki, Y. et al.​ (2021) 
  Cell Death and Differentiation, 28(7) pp. 2207​-2220​.​ DOI: https://doi.org/10.1038/s41418-021-00751-w 
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• 2019 | Journal Article | Research Paper | 
  ​ ​Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression​
  Hasselluhn, M. C.; Schmidt, G. E.; Ellenrieder, V.; Johnsen, S. A. & Hessmann, E. ​ (2019) 
  Cell Death & Disease, 10(6) pp. 446​.​ DOI: https://doi.org/10.1038/s41419-019-1682-2 
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• 2019 | Journal Article | 
  ​ ​Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.​
  Patzak, M. S.; Kari, V.; Patil, S.; Hamdan, F. H.; Goetze, R. G.; Brunner, M. & Gaedcke, J. et al.​ (2019) 
  EBioMedicine, 40 pp. 394​-405​.​ DOI: https://doi.org/10.1016/j.ebiom.2019.01.037 
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• 2018 | Journal Article | 
  ​ ​Epigenetic Targeting of Aberrant Transcriptional Modulation in Pancreatic Cancer​
  Hamdan, F. H. & Johnsen, S. A.​ (2018) 
  Epigenomes, 2(2) pp. 8​.​ DOI: https://doi.org/10.3390/epigenomes2020008 
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• 2018 | Journal Article
  ​ ​Abstract 1472: The role of the BAF complex in Wnt signaling-mediated transcriptional regulation in colorectal cancer​
  Sen, M.; Hamdan, F. H.; Wang, X.; Rapp, J. & Johnsen, S. A.​ (2018) 
  Cancer Research, 78(13_Supplement) pp. 1472​-1472​.​ DOI: https://doi.org/10.1158/1538-7445.AM2018-1472 
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• 2018 | Journal Article
  ​ ​Abstract 1917: CHD1 depletion leads to androgen-independent growth of prostate cancer cells lines and regulates the TGFβ system in an EZH2-dependent manner​
  Böcker, S. J.; Baumgart, S. J.; Roth, A.; Kari, V.; Johnsen, S. A. & Hahn, O.​ (2018) 
  Cancer Research, 78(13_Supplement) pp. 1917​-1917​.​ DOI: https://doi.org/10.1158/1538-7445.AM2018-1917 
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• 2018 | Journal Article
  ​ ​Abstract 3936: Bromodomain testis-specific protein BRDT is expressed in a subset of esophageal squamous cell carcinomas and controls expression of differentiation-associated genes​
  Wang, X.; Hamdan, F. H.; Sen, M.; Kutschat, A. P. & Johnsen, S. A.​ (2018) 
  Cancer Research, 78(13_Supplement) pp. 3936​-3936​.​ DOI: https://doi.org/10.1158/1538-7445.AM2018-3936 
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• 2018 | Journal Article
  ​ ​Abstract 2922: The utility of BET inhibition in the sensitization and re-sensitization of pancreatic cancer cells to paclitaxel​
  Hamdan, F. H.; Kutschat, A. P.; Sen, M.; Wang, X. & Johnsen, S. A.​ (2018) 
  Cancer Research, 78(13_Supplement) pp. 2922​-2922​.​ DOI: https://doi.org/10.1158/1538-7445.AM2018-2922 
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• 2018 | Journal Article | 
  ​ ​CDK4 inhibition diminishes p53 activation by MDM2 antagonists​
  Sriraman, A.; Dickmanns, A.; Najafova, Z.; Johnsen, S. A. & Dobbelstein, M. ​ (2018) 
  Cell Death & Disease, 9(9) art. 918​.​ DOI: https://doi.org/10.1038/s41419-018-0968-0 
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• 2017 | Journal Article | 
  ​ ​Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4-and MYC-dependent manner​
  Mishra, V. K.; Wegwitz, F.; Kosinsky, R. L.; Sen, M. ; Baumgartner, R.; Wulff, T. & Siveke, J. T. et al.​ (2017) 
  Nucleic Acids Research, 45(11) pp. 6334​-6349​.​ DOI: https://doi.org/10.1093/nar/gkx212 
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• 2017 | Journal Article
  ​ ​Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?​
  Hessmann, E. ; Johnsen, S. A.; Siveke, J. T. & Ellenrieder, V.​ (2017) 
  Gut, 66(1) pp. 168​-179​.​ DOI: https://doi.org/10.1136/gutjnl-2016-312539 
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• 2017 | Journal Article | 
  ​ ​BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire​
  Najafova, Z.; Tirado-Magallanes, R.; Subramaniam, M.; Hossan, T.; Schmidt, G.; Nagarajan, S. & Baumgart, S. J. et al.​ (2017) 
  Nucleic Acids Research, 45(1) pp. 127​-141​.​ DOI: https://doi.org/10.1093/nar/gkw826 
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• 2017 | Journal Article | 
  ​ ​BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells​
  Nagarajan, S.; Bedi, U.; Budida, A. ; Hamdan, F. H. ; Mishra, V. K.; Najafova, Z. & Xie, W. et al.​ (2017) 
  Nucleic Acids Research, 45(6) pp. 3130​-3145​.​ DOI: https://doi.org/10.1093/nar/gkw1276 
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